Manduria to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Oria and arrive at Palermo Notarbartolo every about 6 hours on average. If travelling with Trenitalia, you need to know the Manduria to Palermo train schedule: the first train leaves at 21:00, while the last ride is at 21:00. A Manduria to Palermo train cost about 58.7 €. But how long is the train ride from Manduria to Palermo? Your journey takes about 22 hours on average.