Manfredonia to Alpignano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Manfredonia and arrive at Alpignano every about 2 hours on average. If travelling with Trenitalia, you need to know the Manfredonia to Alpignano train schedule: the first train leaves at 06:38, while the last ride is at 20:40. A Manfredonia to Alpignano train cost about 72.0 €. But how long is the train ride from Manfredonia to Alpignano? Your journey takes about 12 hours on average.