Melegnano to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Melegnano and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Melegnano to Syracuse train schedule: the first train leaves at 07:38, while the last ride is at 19:08. A Melegnano to Syracuse train cost about 108.2 €. But how long is the train ride from Melegnano to Syracuse? Your journey takes about 18 hours on average.