Mesagne to Messina trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Mesagne to Messina. Trains leave from Mesagne and arrive at Messina Centrale every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Messina train schedule: the first train leaves at 08:00, while the last ride is at 08:00. A Mesagne to Messina train cost about 59.75 €. But how long is the train ride from Mesagne to Messina? Your journey takes about 12 hours on average.