Mesagne to Quattromiglia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Castiglione Cosentino every about 3 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Quattromiglia train schedule: the first train leaves at 08:00, while the last ride is at 11:01. A Mesagne to Quattromiglia train cost about 14.8 €. But how long is the train ride from Mesagne to Quattromiglia? Your journey takes about 6 hours on average.