Mesagne to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Siracusa every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Syracuse train schedule: the first train leaves at 04:38, while the last ride is at 04:38. A Mesagne to Syracuse train cost about 52.2 €. But how long is the train ride from Mesagne to Syracuse? Your journey takes about 18 hours on average.