Mesagne to Syracuse trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Mesagne to Syracuse. Trains leave from Mesagne and arrive at Siracusa every about 12 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Syracuse train schedule: the first train leaves at 04:38, while the last ride is at 04:38. A Mesagne to Syracuse train cost about 52.2 €. But how long is the train ride from Mesagne to Syracuse? Your journey takes about 18 hours on average.