Mesagne to Varese trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Mesagne and arrive at Varese every about 2 hours on average. If travelling with Trenitalia, you need to know the Mesagne to Varese train schedule: the first train leaves at 07:05, while the last ride is at 18:20. A Mesagne to Varese train cost about 78.0 €. But how long is the train ride from Mesagne to Varese? Your journey takes about 13 hours on average.