Messina to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Comiso every about 4 hours on average. If travelling with Trenitalia, you need to know the Messina to Comiso train schedule: the first train leaves at 12:18, while the last ride is at 16:35. A Messina to Comiso train cost about 13.2 €. But how long is the train ride from Messina to Comiso? Your journey takes about 6 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Messina to Comiso and find low cost tickets starting from 16 €!