Mestre to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Venezia Mestre and arrive at Enna every about 2 hours on average. If travelling with Trenitalia, you need to know the Mestre to Enna train schedule: the first train leaves at 00:21, while the last ride is at 18:37. A Mestre to Enna train cost about 121.35 €. But how long is the train ride from Mestre to Enna? Your journey takes about 17 hours on average.