Molfetta to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Molfetta and arrive at Palermo Notarbartolo every about 3 hours on average. If travelling with Trenitalia, you need to know the Molfetta to Palermo train schedule: the first train leaves at 21:28, while the last ride is at 23:27. A Molfetta to Palermo train cost about 66.2 €. But how long is the train ride from Molfetta to Palermo? Your journey takes about 21 hours on average.