Monopoli to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Monopoli and arrive at Castelvetrano every about 12 hours on average. If travelling with Trenitalia, you need to know the Monopoli to Castelvetrano train schedule: the first train leaves at 23:40, while the last ride is at 23:40. A Monopoli to Castelvetrano train cost about 163.15 €. But how long is the train ride from Monopoli to Castelvetrano? Your journey takes about 22 hours on average.