Niscemi to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Niscemi and arrive at Mazara del Vallo every about 6 hours on average. If travelling with Trenitalia, you need to know the Niscemi to Mazara del Vallo train schedule: the first train leaves at 06:22, while the last ride is at 21:45. A Niscemi to Mazara del Vallo train cost about 18.3 €. But how long is the train ride from Niscemi to Mazara del Vallo? Your journey takes about 14 hours on average.