Novi Ligure to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Novi Ligure and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Novi Ligure to Messina train schedule: the first train leaves at 04:10, while the last ride is at 22:44. A Novi Ligure to Messina train cost about 84.6 €. But how long is the train ride from Novi Ligure to Messina? Your journey takes about 16 hours on average.