Osimo to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Osimo-Castelfidardo, Salerno and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Osimo to Messina train schedule: the first train leaves at 06:44, while the last ride is at 22:01. A Osimo to Messina train cost about 69.75 €. But how long is the train ride from Osimo to Messina? Your journey takes about 13 hours on average. If you need to travel this week, prices start from 45.50€. When booking your train ticket a few weeks in advance though, you can find low cost trains from Osimo to Messina with fares starting from 19.90€, saving up to 56%.