Perugia to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Perugia and arrive at Siracusa every about 6 hours on average. If travelling with Trenitalia, you need to know the Perugia to Syracuse train schedule: the first train leaves at 07:12, while the last ride is at 17:56. A Perugia to Syracuse train cost about 85.7 €. But how long is the train ride from Perugia to Syracuse? Your journey takes about 16 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Perugia to Syracuse and find low cost tickets starting from 49 €!