Pisa to Avola trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Avola every about 2 hours on average. If travelling with Trenitalia, you need to know the Pisa to Avola train schedule: the first train leaves at 07:32, while the last ride is at 19:45. A Pisa to Avola train cost about 100.6 €. But how long is the train ride from Pisa to Avola? Your journey takes about 16 hours on average.