Pisa to Caltagirone trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Caltagirone every about 4 hours on average. If travelling with Trenitalia, you need to know the Pisa to Caltagirone train schedule: the first train leaves at 02:21, while the last ride is at 19:13. A Pisa to Caltagirone train cost about 158.5 €. But how long is the train ride from Pisa to Caltagirone? Your journey takes about 19 hours on average.