Pisa to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Enna every about 4 hours on average. If travelling with Trenitalia, you need to know the Pisa to Enna train schedule: the first train leaves at 00:01, while the last ride is at 19:13. A Pisa to Enna train cost about 75.35 €. But how long is the train ride from Pisa to Enna? Your journey takes about 17 hours on average.