Pisa to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Pisa to Messina train schedule: the first train leaves at 00:01, while the last ride is at 19:13. A Pisa to Messina train cost about 59.0 €. But how long is the train ride from Pisa to Messina? Your journey takes about 12 hours on average. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Pisa to Messina and find low cost tickets starting from 43 €!