Pisa to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Niscemi every about 3 hours on average. If travelling with Trenitalia, you need to know the Pisa to Niscemi train schedule: the first train leaves at 07:32, while the last ride is at 19:45. A Pisa to Niscemi train cost about 97.9 €. But how long is the train ride from Pisa to Niscemi? Your journey takes about 11 hours on average.