Pisa to San Benedetto del Tronto trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Porto D'Ascoli every about 2 hours on average. If travelling with Trenitalia, you need to know the Pisa to San Benedetto del Tronto train schedule: the first train leaves at 06:10, while the last ride is at 14:54. A Pisa to San Benedetto del Tronto train cost about 40.85 €. But how long is the train ride from Pisa to San Benedetto del Tronto? Your journey takes about 6 hours on average.