Pisa to Senigallia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Senigallia every 20 minutes on average. If travelling with Trenitalia, you need to know the Pisa to Senigallia train schedule: the first train leaves at 06:29, while the last ride is at 18:01. A Pisa to Senigallia train cost about 23.6 €. But how long is the train ride from Pisa to Senigallia? Your journey takes about 6 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Pisa to Senigallia and find low cost tickets starting from 25 €!