Pistoia to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pistoia and arrive at Siracusa every about 1 hour on average. If travelling with Trenitalia, you need to know the Pistoia to Syracuse train schedule: the first train leaves at 08:12, while the last ride is at 21:12. A Pistoia to Syracuse train cost about 94.3 €. But how long is the train ride from Pistoia to Syracuse? Your journey takes about 17 hours on average.