Rome to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Roma Termini and arrive at Castelvetrano every about 2 hours on average. If travelling with Trenitalia, you need to know the Rome to Castelvetrano train schedule: the first train leaves at 07:35, while the last ride is at 22:26. A Rome to Castelvetrano train cost about 56.65 €. But how long is the train ride from Rome to Castelvetrano? Your journey takes about 16 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Rome to Castelvetrano and find low cost tickets starting from 68 €!