Rome to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Roma Termini and arrive at Comiso every about 6 hours on average. If travelling with Trenitalia, you need to know the Rome to Comiso train schedule: the first train leaves at 07:35, while the last ride is at 07:35. A Rome to Comiso train cost about 155.45 €. But how long is the train ride from Rome to Comiso? Your journey takes about 15 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Rome to Comiso and find low cost tickets starting from 64 €!