Sant'Anastasia to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Napoli Centrale and arrive at Milazzo every about 2 hours on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Milazzo train schedule: the first train leaves at 15:55, while the last ride is at 23:53. A Sant'Anastasia to Milazzo train cost about 60.0 €. But how long is the train ride from Sant'Anastasia to Milazzo? Your journey takes about 8 hours on average. Trenitalia offers 1 direct trains between these two cities.