Sant'Antimo to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Antimo-S. Arpino and arrive at Palermo Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Sant'Antimo to Palermo train schedule: the first train leaves at 08:23, while the last ride is at 21:14. A Sant'Antimo to Palermo train cost about 64.7 €. But how long is the train ride from Sant'Antimo to Palermo? Your journey takes about 12 hours on average.