Santeramo in Colle to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Santeramo and arrive at Alessandria every about 2 hours on average. If travelling with Trenitalia, you need to know the Santeramo in Colle to Alessandria train schedule: the first train leaves at 07:40, while the last ride is at 07:40. A Santeramo in Colle to Alessandria train cost about 93.4 €. But how long is the train ride from Santeramo in Colle to Alessandria? Your journey takes about 13 hours on average.