Scafati to Isernia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Scafati and arrive at Isernia every about 2 hours on average. If travelling with Trenitalia, you need to know the Scafati to Isernia train schedule: the first train leaves at 09:44, while the last ride is at 17:34. A Scafati to Isernia train cost about 8.2 €. But how long is the train ride from Scafati to Isernia? Your journey takes about 4 hours on average.