Segrate to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Segrate and arrive at Castelvetrano every about 2 hours on average. If travelling with Trenitalia, you need to know the Segrate to Castelvetrano train schedule: the first train leaves at 14:14, while the last ride is at 19:29. A Segrate to Castelvetrano train cost about 115.85 €. But how long is the train ride from Segrate to Castelvetrano? Your journey takes about 14 hours on average.