Segrate to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Segrate and arrive at Mazara del Vallo every about 3 hours on average. If travelling with Trenitalia, you need to know the Segrate to Mazara del Vallo train schedule: the first train leaves at 14:14, while the last ride is at 19:29. A Segrate to Mazara del Vallo train cost about 116.7 €. But how long is the train ride from Segrate to Mazara del Vallo? Your journey takes about 17 hours on average.