Segrate to Mestre trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Porta Garibaldi and arrive at Venezia Mestre every about 4 hours on average. If travelling with Trenitalia, you need to know the Segrate to Mestre train schedule: the first train leaves at 14:12, while the last ride is at 17:12. A Segrate to Mestre train cost about 36.0 €. But how long is the train ride from Segrate to Mestre? Your journey takes about 3 hours on average.