Segrate to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Segrate and arrive at Palermo Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Segrate to Palermo train schedule: the first train leaves at 07:57, while the last ride is at 21:17. A Segrate to Palermo train cost about 116.6 €. But how long is the train ride from Segrate to Palermo? Your journey takes about 18 hours on average.