Senigallia to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Senigallia and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Senigallia to Palermo train schedule: the first train leaves at 13:31, while the last ride is at 21:02. A Senigallia to Palermo train cost about 95.15 €. But how long is the train ride from Senigallia to Palermo? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Senigallia to Palermo and find low cost tickets starting from 64 €!