Senigallia to Palermo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 7 daily rides to get from Senigallia to Palermo. Trains leave from Senigallia and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Senigallia to Palermo train schedule: the first train leaves at 13:31, while the last ride is at 21:02. A Senigallia to Palermo train cost about 95.15 €. But how long is the train ride from Senigallia to Palermo? Your journey takes about 20 hours on average.