Seregno to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Seregno and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Seregno to Niscemi train schedule: the first train leaves at 17:30, while the last ride is at 19:30. A Seregno to Niscemi train cost about 117.05 €. But how long is the train ride from Seregno to Niscemi? Your journey takes about 13 hours on average.