Sesto San Giovanni to Agrigento trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sesto S. Giovanni and arrive at Agrigento Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Agrigento train schedule: the first train leaves at 19:31, while the last ride is at 21:53. A Sesto San Giovanni to Agrigento train cost about 81.05 €. But how long is the train ride from Sesto San Giovanni to Agrigento? Your journey takes about 23 hours on average.