Sesto San Giovanni to Alpignano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sesto S. Giovanni and arrive at Alpignano every 60 minutes on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Alpignano train schedule: the first train leaves at 06:46, while the last ride is at 07:43. A Sesto San Giovanni to Alpignano train cost about 12.95 €. But how long is the train ride from Sesto San Giovanni to Alpignano? Your journey takes about 3 hours on average.