Sesto San Giovanni to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sesto S. Giovanni and arrive at Castelvetrano every about 6 hours on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Castelvetrano train schedule: the first train leaves at 16:31, while the last ride is at 19:27. A Sesto San Giovanni to Castelvetrano train cost about 124.45 €. But how long is the train ride from Sesto San Giovanni to Castelvetrano? Your journey takes about 11 hours on average.