Sienna to Ancona trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Ancona every 60 minutes on average. If travelling with Trenitalia, you need to know the Sienna to Ancona train schedule: the first train leaves at 06:00, while the last ride is at 18:47. A Sienna to Ancona train cost about 29.65 €. But how long is the train ride from Sienna to Ancona? Your journey takes about 6 hours on average.