Sienna to Mazara del Vallo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 3 daily rides to get from Sienna to Mazara del Vallo. Trains leave from Siena and arrive at Mazara del Vallo every about 4 hours on average. If travelling with Trenitalia, you need to know the Sienna to Mazara del Vallo train schedule: the first train leaves at 17:43, while the last ride is at 18:43. A Sienna to Mazara del Vallo train cost about 160.9 €. But how long is the train ride from Sienna to Mazara del Vallo? Your journey takes about 21 hours on average.