Sienna to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Mazara del Vallo every about 4 hours on average. If travelling with Trenitalia, you need to know the Sienna to Mazara del Vallo train schedule: the first train leaves at 17:43, while the last ride is at 18:43. A Sienna to Mazara del Vallo train cost about 160.9 €. But how long is the train ride from Sienna to Mazara del Vallo? Your journey takes about 21 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Mazara del Vallo and find low cost tickets starting from 79 €!