Sienna to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Siracusa every about 1 hour on average. If travelling with Trenitalia, you need to know the Sienna to Syracuse train schedule: the first train leaves at 06:00, while the last ride is at 21:26. A Sienna to Syracuse train cost about 91.05 €. But how long is the train ride from Sienna to Syracuse? Your journey takes about 18 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Syracuse and find low cost tickets starting from 103 €!