Spoleto to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Spoleto and arrive at Alessandria every 60 minutes on average. If travelling with Trenitalia, you need to know the Spoleto to Alessandria train schedule: the first train leaves at 06:12, while the last ride is at 22:26. A Spoleto to Alessandria train cost about 63.15 €. But how long is the train ride from Spoleto to Alessandria? Your journey takes about 9 hours on average.