Spoleto to Comiso trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Spoleto to Comiso. Trains leave from Spoleto and arrive at Comiso every about 6 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Comiso train schedule: the first train leaves at 19:00, while the last ride is at 19:00. A Spoleto to Comiso train cost about 112.1 €. But how long is the train ride from Spoleto to Comiso? Your journey takes about 18 hours on average.