Spoleto to Varese trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Spoleto and arrive at Varese every about 3 hours on average. If travelling with Trenitalia, you need to know the Spoleto to Varese train schedule: the first train leaves at 12:06, while the last ride is at 22:26. A Spoleto to Varese train cost about 59.4 €. But how long is the train ride from Spoleto to Varese? Your journey takes about 10 hours on average.