Tortona to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Tortona and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Tortona to Niscemi train schedule: the first train leaves at 21:02, while the last ride is at 21:39. A Tortona to Niscemi train cost about 77.0 €. But how long is the train ride from Tortona to Niscemi? Your journey takes about 8 hours on average.