Varese to Manfredonia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Varese and arrive at Manfredonia every about 6 hours on average. If travelling with Trenitalia, you need to know the Varese to Manfredonia train schedule: the first train leaves at 08:06, while the last ride is at 19:36. A Varese to Manfredonia train cost about 72.0 €. But how long is the train ride from Varese to Manfredonia? Your journey takes about 10 hours on average.