Afragola to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casoria-Afragola and arrive at Niscemi every about 3 hours on average. If travelling with Trenitalia, you need to know the Afragola to Niscemi train schedule: the first train leaves at 08:46, while the last ride is at 22:30. A Afragola to Niscemi train cost about 62.55 €. But how long is the train ride from Afragola to Niscemi? Your journey takes about 17 hours on average.