Alpignano to Manfredonia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Alpignano and arrive at Manfredonia every about 2 hours on average. If travelling with Trenitalia, you need to know the Alpignano to Manfredonia train schedule: the first train leaves at 07:55, while the last ride is at 19:25. A Alpignano to Manfredonia train cost about 66.0 €. But how long is the train ride from Alpignano to Manfredonia? Your journey takes about 10 hours on average.