Ancona to Manfredonia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Ancona and arrive at Manfredonia every about 2 hours on average. If travelling with Trenitalia, you need to know the Ancona to Manfredonia train schedule: the first train leaves at 13:34, while the last ride is at 16:29. A Ancona to Manfredonia train cost about 45.8 €. But how long is the train ride from Ancona to Manfredonia? Your journey takes about 4 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Ancona to Manfredonia and find low cost tickets starting from 37 €!