Avezzano to Isernia trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Avezzano and arrive at Isernia every about 2 hours on average. If travelling with Trenitalia, you need to know the Avezzano to Isernia train schedule: the first train leaves at 06:56, while the last ride is at 16:14. A Avezzano to Isernia train cost about 17.7 €. But how long is the train ride from Avezzano to Isernia? Your journey takes about 6 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Avezzano to Isernia and find low cost tickets starting from 10 €!